KEGG   Homo sapiens (human): 7084
Entry
7084              CDS       T01001                                 
Symbol
TK2, MTDPS2, MTTK, PEOB3, SCA31, TK2-EXT
Name
(RefSeq) thymidine kinase 2
  KO
K00857  thymidine kinase [EC:2.7.1.21]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00240  Pyrimidine metabolism
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa01232  Nucleotide metabolism
Disease
H00469  Mitochondrial DNA depletion syndrome
H01395  Autosomal recessive progressive external ophthalmoplegia
Drug target
Doxecitine: D12465
Doxribtimine: D12466
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    7084 (TK2)
  09111 Xenobiotics biodegradation and metabolism
   00983 Drug metabolism - other enzymes
    7084 (TK2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.21  thymidine kinase
     7084 (TK2)
SSDB
Motif
Pfam: dNK AAA_33 AAA_18 Thymidylate_kin AAA_17 AAA_22 TsaE
Other DBs
NCBI-GeneID: 7084
NCBI-ProteinID: NP_004605
OMIM: 188250
HGNC: 11831
Ensembl: ENSG00000166548
UniProt: O00142 Q8IZR3
Position
16:complement(66508003..66550291)
AA seq 265 aa
MLLWPLRGWAARALRCFGPGSRGSPASGPGPRRVQRRAWPPDKEQEKEKKSVICVEGNIA
SGKTTCLEFFSNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDR
HTRPQVSSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIV
YLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHH
MERMLELFEQNRDRILTPENRKHCP
NT seq 798 nt   +upstreamnt  +downstreamnt
atgctgctgtggccgctgcggggctgggccgcccgggcgctgcgctgctttgggccggga
agtcgcgggagcccggcctcaggccccgggccgcggagggtgcagcgccgggcctggcct
cccgataaagaacaggaaaaagagaaaaaatcagtgatctgtgtcgagggcaatattgca
agtgggaagacgacatgcctggaattcttctccaacgcgacagacgtcgaggtgttaacg
gagcctgtgtccaagtggagaaatgtccgtggccacaatcctctgggcctgatgtaccac
gatgcctctcgctggggtcttacgctacagacttatgtgcagctcaccatgctggacagg
catactcgtcctcaggtgtcatctgtacggttgatggagaggtcgattcacagcgcaaga
tacatttttgtagaaaacctgtatagaagtgggaagatgccagaagtggactatgtagtt
ctgtcggaatggtttgactggatcttgaggaacatggacgtgtctgttgatttgatagtt
taccttcggaccaatcctgagacttgttaccagaggttaaagaagagatgcagggaagag
gagaaggtcattccgctggaatacctggaagcaattcaccatctccatgaggagtggctc
atcaaaggcagccttttccccatggcagcccctgttctggtgattgaggctgaccaccac
atggagaggatgttagaactctttgaacaaaatcgggatcgaatattaactccagagaat
cggaagcattgcccatag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (4)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Drug (2)   
   KEGG DRUG (2)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (19)   
   KEGG ORTHOLOGY (1)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (10)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (57)   
   RefSeq(nuc) (9)   
   GenBank (24)   
   EMBL (24)   
Protein domain (7)   
   Pfam (7)   
All databases (119)   

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